Absolutely. The location of the supply and exhaust (return) air grilles should take the highest priority when laying out the cleanroom. The supply (from the ceiling) and return air grilles (at a low level) should be at the opposite sides of the cleanroom to facilitate a “plug” flow effect. If the operator needs to be protected from a high-potency product, for example, the flow should be away from the operator.
For a sterile or aseptic process that needs Grade A air, the airflow typically mimics a plug flow from top to bottom and is unidirectional or “laminar.” Careful consideration should be given to ensuring that the “first air” is never contaminated before it comes into contact with the product. CE has decades of experience designing mechanical systems within critical environments. Contact us for help deigning your cleanroom.